Reversine
Reverses differentiated cells to multipotent stem cells / Induces differentiated myogenic-lineage-committed cells to become multipotent mesenchymal progenitor cells.1-2 Acts as a selective human A3 adenosine receptor antagonist (Ki = 0.66 µM).3 Cell permeable.
Biochemicals & reagents
656820-32-5
1) Chen et al. (2004), Dedifferentiation of lineage-committed cells by a small molecule; J. Am. Chem. Soc., 126 410 2) Chen et al. (2007), Reversine increases the plasticity of lineage-committed mammalian cells; Proc. Natl. Acad. Sci. USA, 104 10482 3) Perreira et al. (2005), “Reversine” and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists; J. Med. Chem., 48 4910
-20°C
TARGET: GPCR; Kinase -- PATHWAY: Cell cycle -- RESEARCH AREA: Stem cells