Deltamethrin
Calcineurin inhibitor; displays neurotrophic activity / Reported to be an inhibitor of calcineurin (PP2B), IC50~100 pM1 but this activity has been disputed2. Markedly enhances the expression of BDNF in cultured rat cortical neurons and displays neurotrophic effects.3 Produces antidepressant-like effects in mice.4 Blocks the spontaneous down-regulation of Nav1.8 sodium channels expressed in Xenopus oocytes.5
Biochemicals & reagents
52918-63-5
Decamethrin
1) Enan et al. (1992), Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides; Biochem. Pharmacol., 43 1777 2) Swingle et al. (2007), Small-molecules inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse; Methods Mol. Biol., 365 23 3) Ihara et al. (2012), Deltamethrin, a type II pyrethroid insecticide, has neurotrophic effects on neurons with continuous activation of the Bdnf promoter; Neuropharmacology, 62 1091 4) Takasaki et al. (2013), Type II pyrethroid deltamethrin produces antidepressant-like effects in mice; Behav. Brain Res., 257 182 5) Choi & Soderlund (2004), Cyclopsorin A and deltamethrin block the downregulation of Nav1.8 sodium channels expressed in Xenopus oocytes; Neurosci. Lett., 367 389
-20°C
TARGET: Phosphatase; Ion channel -- PATHWAY: Sodium channel; Neurotrophin -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Mood disorders