ß-Lapachone
Topoisomerase I inhibitor / A naturally occurring quinone found in the bark of the Lapacho tree (Tabebuia avellanedae). A novel DNA topoisomerase I inhibitor which unlike camptothecin does not stabilize the cleavable complex indicating a novel mode of action.1 Induces apoptosis in a number of cancer cell lines.2 In cancer cells overexpressing NAD(P)H:quinone oxidoreductase, reduction of -lapachone leads to futile cycling between quinone and hydroquinone forms3 resulting in the production of reactive oxygen species4. Suppresses radiation-induced activation of NFB.5
Biochemicals & reagents
4707-32-8
NSC-26326
1) Li et al. (1993), beta-lapachone, a Novel DNA Topoisomerase I Inhibitor With a Mode of Action Different From Camptothecinr; J. Biol. Chem., 268 22463 2) Wuerzberger et al. (1998), Induction of Apoptosis in MCF-7:WS8 Breast Cancer Cells by Beta-Lapachone; Cancer Res., 58 1876 3) Pink et al. (2000), NAD(P)H:Quinone Oxidoreductase Activity Is the Principal Determinant of Beta-Lapachone Cytotoxicity. J. Biol. Chem., 275 5416 4) Siegel et al. (2012), NAD(P)H:quinone Oxidoreductase 1 (NQO1) in the Sensitivity and Resistance to Antitumor Quinones; Biochem. Phramacol., 83 1033 5) Dong et al. (2010), Beta-lapachone suppresses radiation-induced activation fo nuclear factor-kappaB; Exp. Mol. Med., 42 327
-20°C
TARGET: Topoisomerase; DNA -- PATHWAY: DNA synthesis; Transcription; Apoptosis inducer; Cell cycle; Redox; NAD, NADP pathways -- RESEARCH AREA: Cell death; Oxidative stress -- DISEASE AREA: Cancer; InflammationParasites; Ischemia; Kidney disease