Topotecan HCl
DNA topoisomerase I inhibitor / Topotecan HCl is a water-soluble and orally active analog of camptothecin, a DNA topoisomerase I inhibitor.1 Inhibits topoisomerase I in human MCF-7 breast and DU-145 prostate cancer cells, IC50s = 13 and 2 nM respectively.2 Downregulates B-Myb and MycN expression in neuroblastoma cells.3 A clinically useful anticancer agent.
Biochemicals & reagents
119413-54-6
NSC 609669; SKF-104864A
1 Schellens et al. (1996), Bioavailability and pharmacokinetics of oral topotecan: a new topoisomerase I inhibitor; Br. J. Cancer 73 1268 2 Caceres et al. (2003), Determination of chemotherapeutic activity in vivo by luminescent imaging of luciferase-transfected human tumors; Anticancer Drugs 14 569 3 Sottile et al. (2012), A chemical screen identifies the chemotherapeutic drug topotecan as a specific inhibitor of the B-MYB/MYCN axis in neuroblastoma; Oncotarget 3 535
-20°C
TARGET: Topoisomerase; DNA -- PATHWAY: DNA synthesis; Transcription; Myc -- DISEASE AREA: Cancer