ICRF-193
Topoisomerase II inhibitor / ICRF-193 is a topoisomerase II poison.1 Toposiomerase poisons are a special subclass of topoisomerase inhibitors that stabilize topoisomerase-DNA strand passing intermediates and thus cause the topoisomerases to become a cytotoxic DNA-damaging agent.1 It readily induces DNA strand breaks in V79 and irs-2 Chinese hamster lung fibroblasts via a novel mechanism.2 Displays cardioprotective (against anthracycline toxicity)3 and anti-inflammatory effects via reduction of IL-1β secretion by macrophages4. An important tool for studying the cellular response to DNA double-strand breaks.5
Biochemicals & reagents
21416-88-6
1 Huang et al. (2001), Topoisomerase II Poisoning by ICRF-193; J. Biol. Chem. 276 44488 2 Hajji et al. (2003), DNA strand breaks induced by the anti-topoisomerase bis-dioxopiperazine ICRF-193; Mutat. Res. 530 35 3 Jirkovskai et al. (2021), Structure-Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIß Interactions; J. Med. Chem. 64 3997 4 Brindle et al. (2024), The Bisdioxopiperazine ICRF-193 Attenuates LPS-induced IL-1ß Secretion by Macrophages; Inflammation 47 84 5 Morotomi-Yano et al. (2018), Dynamic behavior of DNA topoisomerase IIß in response to DNA double-strand breaks; Sci. Rep. 8 10344
-20°C
TARGET: Topoisomerase; DNA -- PATHWAY: DNA damage; Cell cycle; Cytokine -- DISEASE AREA: Cancer; Inflammation