Cilastatin Na
Protease inhibitor / Dehydropeptidase-1 inhibitor. Inhibits the proteolytic conversion of leukotriene D4 to E4.1 Inhibits the mammalian β-lactamase renal dipeptidase (dehydropeptidase-1, DPEP1) and thus is used as an antibacterial adjunct to extend the half-life of β-lactam antibiotics.2 Cilastatin also inhibits bacterial metallo-β-lactamase and thereby may block resistance to the carbapenem family of antibiotics in certain bacteria.3 Suppresses invasion and metastasis of DPEP1-expressing tumor cells.4
Biochemicals & reagents
81129-83-1
MK 0791
1) White et al. (1999), A continuous fluorometric assay for Leukotriene D4 hydrolase; Anal. Biochem., 268 245 2) Graham et al. (1987), Inhibition of the mammalian beta-lactamase renal dipeptidase (dehydropeptidase-I) by (Z)-2-acylamino-3-substituted propenoic acids; J. Med. Chem., 30 1074 3) Keynan et al. (1995), The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA; Antimicreob. Agents Chemother., 39 1629 4) Park et al. (2016), Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer; Oncotarget, 7 9501
-20°C
TARGET: Protease; Antibiotic -- PATHWAY: Lipid signaling -- DISEASE AREA: Cancer; Infectious disease