Minocycline HCl
Neuroprotective; antiapoptotic / Displays antiapoptotic, anti-inflammatory1 activity. Prevents neuropathic pain in a rat sciatic nerve injury model1. Reduces MMP-9 activity2. Attenuates disease severity in mouse models of multiple sclerosis3. Displays neuroprotective activity4. May be effective in methotrexate-induced lung fibrosis5. Orally active and brain penetrant.
Biochemicals & reagents
13614-98-7
1) Padi and Kulkarni (2008), Minocycline prevents the development of neuropathic pain, but not acute pain: possible anti-inflammatory and antioxidant mechanisms; Eur. J. Pharmacol., 601 79 2) Dziembowska et al. (2013), High MMP-9 activity levels in fragile X syndrome are lowered by minocycline; Am. J. Med. Genet. A, 161A 1897 3) Brundula et al. (2002), Targeting leukocyte MMPs and transmigration: minocycline as a potential therapy for multiple sclerosis; Brain., 125 1297 4) Tikka et al. (2001), Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia; J. Neurosci., 21 2580 5) Kalemci et al. (2013), The efficacy of minocycline against methotrexate-induced pulmonary fibrosis in mice; Eur. Rev. Med. Pharmacol. Sci., 17 3334
-20°C
TARGET: PARP; Antibiotic -- PATHWAY: Apoptosis inhibitor; DNA repair -- RESEARCH AREA: Neuroscience; Immunology; Cell death; Stem cells -- DISEASE AREA: Inflammation; PainInfectious disease; Neurodegeneration