17-GMP-APA-GA
Geldanamycin with ADC linker / Geldanamycin analog equipped with linker for coupling to proteins or antibodies for the preparation of immunoconjugates, for example.
Biochemicals & reagents
Unknown
1) Mandler et al. (2004), Herceptin-geldanamycin immunoconjugates: pharmacokinetics, biodistribution, and enhanced antitumor activity; Cancer Res., 64 1460 / 2) Mandler et al. (2002), Modifications in synthesis strategy improve the yield and efficacy of geldanamycin-herceptin immunoconjugates; Bioconj. Chem., 13 786 / Mandler et al. (2000), Immunoconjugates of geldanamycin and anti-HER2 monoclonal antibodies: antiproliferative activity on human breast carcinoma cell lines; J. Natl. Cancer Inst., 92 1573
-20°C
TARGET: HSP (Heat shock protein); Antibiotic -- PATHWAY: Autophagy -- RESEARCH AREA: Ubiquitin/Proteasome; Cell death; Cellular stress -- DISEASE AREA: Cancer; Infectious disease