Geldanamycin
HSP90 inhibitor / Inhibits HSP90 by binding to its ATP-binding domain (Kd=1.2 µM) and subsequently inhibits HSP90 client proteins. Induces apoptosis in various cell types. Cell permeable.
Biochemicals & reagents
30562-34-6
Ro 1722; Ro 15-1788
1) Neckers et al., (1999), Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity; Invest. New Drugs 17 361 / 2) Zang et al., (2006), HSP90 protects apoptotic cleavage of vimentin in geldanamycin-induced apoptosis; Mol. Cell. Biochem. 281 111
-20°C
TARGET: HSP (Heat shock protein); Antibiotic -- PATHWAY: Cell cycle; Apoptosis inducer; Autophagy; PI3K; Senolytic agent -- RESEARCH AREA: Cellular stress; Cell death; Ubiquitin/Proteasome -- DISEASE AREA: Cancer; Infectious disease