D(+)-Cycloserine
NMDA, glycine site partial agonist / Partial agonist at the glycine modulatory site of NMDA glutamatergic receptors1. Blocks kainate-induced seizures2 and displays anticonvulsant effects3 in rat models. Facilitates synaptic plasticity but impairs glutamatergic neurotransmission in rat hippocampal slices4. Enhances activity-dependent plasticity in human adults5.
Biochemicals & reagents
68-41-7
1) Watson et al. (1990), D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes; Brain Res., 510 158 2) Baran et al. (1994), The glycine/NMDA receptor partial agonist D-cycloserine blocks kainite-induced seizures in rats. Comparison with MK-801 and diazepam; Brain Res., 652 195 3) Löscher et al. (1994), Anticonvulsant effects of the glycine/NMDA receptor ligands D-cycloserine and D-serine but not R(+)-HA-966 in amygdala-kindled rats; Br. J. Phamracol., 112 97 4) Rouaud and Billard (2003), D-cycloserine facilitates synaptic plasticity but impairs glutamatergic neurotransmission in rat hippocampal slices; Br. J. Pharmacol., 140 1051 5) Forsyth et al. (2015), Augmenting NMDA receptor signaling boosts experience-dependnet neuroplasticity in the adult human brain; Proc. Natl. Acad. Sci. USA, 112 15331
-20°C
TARGET: Ion channel; Antibiotic -- PATHWAY: Cation channel; Sphingolipid metabolism -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Inflammation; Infectious disease