17-DMAG
HSP90 inhibitor / Geldanamycin analog that displays superior pharmacological properties. Inhibits HSP90 and induces apoptosis in a variety of tumor cell lines. Inhibits angiogenesis. Cell Permeable.
Biochemicals & reagents
467214-20-6
NSC 707545; KOS-1022; Alvespimycin
1) Glaze et al. (2005), Preclinical toxicity of geldanamycin analog 17-(dimethylaminoethylamino)-demthoxygeldanamycin (17-DMAG) in rats and dogs; potential clinical relevance ; Cancer Chemother. Pharmacol., 56 637 / 2) Kaur et al. (2004), Antiangiogenic properties of 17-(dimethylaminoethylamino)-17-demthoxygeldanamycin: an orally bioavailable heat shock protein 90 modulator; Clin. Cancer Res., 10 4813
-20°C
TARGET: HSP (Heat shock protein); Antibiotic -- PATHWAY: Apoptosis inducer; NFkappaB; Cytokine; Autophagy; Senescence -- RESEARCH AREA: Cell death; Angiogenesis; Ubiquitin/Proteasome; Cellular stress -- DISEASE AREA: Cancer; Infectious disease