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Thapsigargin

Supplier:
Catalogue number:
10-2105-01
Size:
1 mg
Product is available in:
  • USA
  • Canada
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SERCA inhibitor / Potent inhibitor of sarco-endoplasmic reticulum Ca2+ -ATPase1. (IC50= 30 nM) Induces endoplasmic reticulum stress and autophagy in a variety of cell lines2. Warning: highly irritant to skin and mucus membranes.

Product Type:

Biochemicals & reagents

CAS Number:

67526-95-8

Reference:

1) Treiman et al. (1998), A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases; Trends Pharmacol. Sci., 19 131 2) Zhou et al. (2009), Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticulum stress-induced insulin resistance; Mol. Pharmacol., 76 596

Storage Temperature:

-20°C

Additional Information:

TARGET: ATPase; ER/Golgi; UPR (Unfolded protein response) -- PATHWAY: Autophagy; Carbohydrate metabolism; Calcium signaling; NFkappaB -- RESEARCH AREA: Cellular stress; Cell death; Vesicles -- DISEASE AREA: Diabetes