Patulin
Oxidative- and ER-stress inducer / A mycotoxin found in contaminated fruits. Increases ROS generation and oxidative stress in cells which is mediated by p53.1 Displays cytotoxic effects on a variety of cell lines.2 Causes damage to several organs including liver and kidney in laboratory animals.3 Triggers NRF2-mediated survival mechanisms in kidney cells.4 Induces apoptosis through a ROS-mediated ER stress pathway.5
Biochemicals & reagents
149-29-1
Clavacin; Mycoin; Penicidin; Terinin; NSC8120
1) Jin et al. (2016), p53 activation contributes to patulin-induced nephrotoxicity via modulation of reactive oxygen species generation; Sci. Rep., 6 24455 2) Zouaoui et al. (2016), Cytotoxic effects induced by patulin, sterigmatocystin and beauvericin on CHO-K1 cells; Food Chem. Toxicol., 89 92 3) Boussabbeh et al. (2016), Tissue oxidative stress induced by patulin and protective effect of crocin; Neurotoxicology, 53 343 4) Pillay et al. (2015), Patulin triggers NRF2-meditated survival mechanisms in kidney cells; Toxicon, 99 1 5) Boussabbeh et al. (2015), Patulin induces apoptosis through ROS-mediated endoplasmic reticulum stress pathway; Toxicol. Sci., 144 328
-20°C
TARGET: ER/Golgi; Antibiotic; UPR (Unfolded protein response) -- PATHWAY: Redox; Apoptosis inducer; Cytotoxicity; p53 -- RESEARCH AREA: Cell death; Cellular stress -- DISEASE AREA: Kidney disease; Infectious disease