Phenylbutyrate Na
HDAC inhibitor / Histone deacetylase (HDAC) inhibitor. Inhibits proliferation, migration and invasion of a number of cancer cell lines. Induces differentiation, and apoptosis. Active in vivo.
Biochemicals & reagents
1716-12-7
4-PB; PBNa
1) Engelhard et al. (1998), Inhibitory effects of phenylbutyrate on the proliferation, morphology, migration and invasiveness of malignant glioma cells; J. Neuro-Oncol., 37 97 / 2) Appelskog et al. (2004), Histone deacetylase inhibitor 4-phenylbutyrate suppresses GAPDH mRNA expression in glioma cells; Int. J. Oncol., 24 1419
RT
TARGET: Protein deacetylase; ER/Golgi; UPR (Unfolded protein response) -- PATHWAY: Chromatin; Apoptosis inducer; Posttranslational modification; Proliferation; Cell migration -- RESEARCH AREA: Epigenetics; Cell death; Stem cells; Cellular stress -- DISEASE AREA: Diabetes; AtherosclerosisNeurodegeneration