Norfluoxetine HCl
Fluoxetine metabolite / Metabolite of fluoxetine.3 Induces long QT syndrome via slow delayed rectifier potassium current block.1 Time dependent inhibitor of CYP2C19 and CYP3A4.2 The S-isomer of desmethylfluoxetine is the active N-demethylated metabolite responsible for the persistently potent and selective inhibition of serotonin uptake in vivo.3 Potent inhibitor of coxsackievirus replication acting via inhibition of viral RNA synthesis.4 State-dependent TREK-2 blocker.5
Biochemicals & reagents
57226-68-3
Desmethylfluoxetine
1) Veerman et al. (2013), Slow delayed rectifier potassium current blockade contributes importantly to drug-induced long QT syndrome; Circ.Arrythm.Electrophysiol. 6 1002 2) Lutz et al. (2013), Stereoselective inhibition of CYP2C1 and CYP3A4 by fluoxetine and its metabolite: implications for risk assessment of multiple time-dependent inhibitor systems; Drug Metab.Dispos. 41 2056 3) Wong et al. (1993), Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain; Neuropsychopharmacology 8 337 4) Zuo et al. (2012), Fluoxetine is a potent inhibitor of coxsackievirus replication.; Antimicrob.Agents Chemother. 56 4838 5) McClenaghan et al. (2016), Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states; J.Gen.Physiol. 147 497
-20°C
TARGET: Monoamine transporter; Serotonin; Cytochrome/MDR -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Inflammation; Mood disordersInfectious disease