Manidipine dihydrochloride
Calcium channel blocker / SARS-CoV2 3CLpro inhibitor / Manidipine is a clinically useful antihypertensive.1,2 It is an inhibitor of L- and T-type calcium channels with high selectivity for vasculature. Manidipine has recently been found to be an inhibitor (IC50 = 4.8 µM) of the SARS-CoV-2 main protease, 3CLpro.3 It also acts as an early entry inhibitor of human cytomegalovirus (EC50 = 3.57 µM) via inhibition of the Immediate-Early 2 (IE2) protein.4
Biochemicals & reagents
89226-75-5
CV-4093·2HCl; Franidipine·2HCl
1) Kakihana et al. (1988), Antihypertensive effect of CV-4093·2HCl, a new calcium antagonist, in three rat models of hypertension; Jpn. J. Pharmacol., 48 223 2) McKeage (2004), Manidipine: a review of its use in the management of hypertension; Drugs, 64 1923 3) Ghahremanpour et al. (2020), Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2; ACS Med. Chem. Lett., 11 2526 4) Mercorelli et al. (2018), Repurposing the clinically approved calcium antagonist manidipine dihydrochloride as a new early entry inhibitor of human cytomegalovirus targeting the Immediate-Early 2 (IE2) protein; Antiviral Res., 150 130
RT
TARGET: Ion channel; Protease; Cytochrome/MDR -- PATHWAY: Calcium signaling -- DISEASE AREA: Hypertension; Infectious disease