Perphenazine
Antipsychotic agent / Perphenazine is a clinically useful typical antipsychotic drug. The therapeutic mode of action is not well understood but it binds to a wide variety of receptors including serotonin, histamine, dopamine, and α-adrenergic.1 Perphenazine is an inhibitor of acid sphingomyelinase(ASM)2 and positively effected xenografted tumor growth via perturbation of intracellular cholesterol transport through ASM3. It has also been shown to be an inhibitor of glutamate dehydrogenase.4
Biochemicals & reagents
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1) Kroeze et al. (2003), H1-Histamine Receptor Affinity Predicts Short-Term Weight Gain for Typical and Atypical Antipsychotic Drugs; Neuropharmacology 28 519 2) Kornhuber et al. (2011), Identification of Novel Functional Inhibitors of Acid Sphingomyelinase; PLoS One 6 e23852 3) Kuzu et al. (2017), Modulating cancer cell survival by targeting intracellular cholesterol transport; Br.J.Cancer epub ahead of print 4) Couee and Tipton (1990), Inhibition of ox brain glutamate by perphenazine; Biochem.Pharmacol. 39 1167
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TARGET: Monoamine receptor; Serotonin; Dehydrogenase (GAPDH, GPDH, IMPDH, PHGDH, LDH, DHODH, ALDH, GDH, IDH, UGDH, DPD, DHPDH, and MDH) -- PATHWAY: Amino acid metabolism; Histamine -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Mood disorders