PODS® Human Oncostatin M

PODS® Human Oncostatin M contains the polyhedrin protein co-crystalized with Human Oncostatin M. Oncostatin M (OSM) is a member of the LIF/OSM family of proteins that participates in the regulation of haematopoiesis, neurogenesis, osteogenesis and inflammation. OSM can stimulate proliferation of cells such as fibroblasts and smooth muscle cells, but can also induce inhibitory effects on certain tumor cells lines. Furthermore, OSM regulates production and subsequent secretion of cytokines like IL-6, GM-CSF and G-CSF from endothelial cells. Human OSM shares 45% amino acid sequence homology with mouse and rat OSM and is active on murine cells.