PODS® Human Thrombopoietin

PODS® Human Thrombopoietin contains the polyhedrin protein co-crystalized with Human Thrombopoietin. Thrombopoietin (THPO) is a key regulator of the cellular development processes that lead to platelet production, including differentiation, proliferation and maturation of megakaryocytes. THPO is a growth factor that also promotes platelet activation, aggregation and ECM adhesion. Furthermore, THPO can act in coordination with cytokines such as IL-3, IL-6 or IL-11, particularly during the early stages of thrombopoiesis. Separately from its hematopoietic effects, THPO is also expressed in the brain where it can inhibit neuronal differentiation as well as promote apoptosis of hypoxia-sensitised neurons.