PODS® Human CXCL1

PODS® Human CXCL1 contains the polyhedrin protein co-crystalized with Human CXCL1. Also known as GRO-alpha, CXCL1 is a member of the CXC subfamily of chemokines. It is a proinflammatory cytokine and a potent neutrophil attractant, playing a role in neutrophil migration and activation. CXCL1 is both structurally and functionally related to CXCL2 and CXCL3, all of which signal primarily via the IL-8 receptor type B. In vitro, CXCL1 is cleaved into three isoforms, CXCL1(4-73), CXCL1(5-73) and CXCL1(6-73), each of which shows higher chemotactic activity than the full-length protein. CXCL1 is known to be overexpressed constitutively in tumorigenic cells, with elevated levels seen in several tumour types. Human CXCL1 shares 64% and 67% aa sequence identity with mouse and rat CXCL1, respectively.