PODS® Human CXCL8 / IL-8

PODS® Human CXCL8 / IL-8 contains the polyhedrin protein co-crystalized with Human mature IL-8 (amino acids 23-99) which lacks the signal peptide and MDNCFα fragment. IL-8, also known as CXCL8 is a member of the CXC subfamily of chemokines and a major mediator of the inflammatory response. IL-8 functions as a chemotactic factor that attracts neutrophils as well as other granulocytes to sites of inflammation. It is secreted by several cell types including mononuclear macrophages, neutrophils, eosinophils, T-lymphocytes, fibroblast and epithelial cells in response to inflammatory stimuli. IL-8 also plays important functions in neutrophil activation, tumour migration, invasion and angiogenesis.