PODS® Human CDNF

PODS® Human CDNF contains the polyhedrin protein co-crystalized with Human CDNF. Cerebral Dopamine Neurotrophic Factor (CDNF) and MANF (mesencephalic-astrocyte-derived neurotrophic factor) are structural homologues and share 62% amino acid (aa) identity. Furthermore, CDNF is highly conserved across species. It shares 80%, 84%, 90% and 92% aa identity with mouse, rat, equine and bovine CDNF, respectively. Like MANF and GDNF, CDNF is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine-specific neurons (DNs) in vitro. Additionally, in rat Parkinson's disease models that rely on 6-hydroxydopamine (6-OHDA)-induced degeneration of DNs, CDNF can also promote rescue and restoration of DNs in the substania nigra in vivo.