LentiBOOST® is a highly effective, non-cytotoxic transduction enhancer for preclinical and clinical application of lentiviral vectors. As universally acting (receptor independent) adjuvant it can be applied to a wide range of clinically relevant cell types including CD34+ hematopoietic stem cells (HSCs), primary T cells and NK cells. These unique features make it a promising candidate to improve clinical transduction protocols for ex vivo gene therapies and CAR-T cell therapies.
- Applications:The substance has become the gold standard for lentiviral transduction of HSCs. Latest results show consistently increased VCN (Vector Copy Number) per cell in the range of 3 copies per genome and high gene expression in patients 6 month after HSC therapy. This effect of an increase of vector copy numbers can also be observed for T-cells, leading to a higher transduction efficiency applying LentiBOOST®, which in return allows higher levels of expression of your therapeutic proteins.