LentiBOOST® is a highly effective, non-cytotoxic transduction enhancer for preclinical and clinical application of lentiviral vectors. As universally acting (receptor independent) adjuvant it can be applied to a wide range of clinically relevant cell types including CD34+ hematopoietic stem cells (HSCs), primary T cells and NK cells. These unique features make it a promising candidate to improve clinical transduction protocols for ex vivo gene therapies and CAR-T cell therapies.
The substance has become the gold standard for lentiviral transduction of HSCs. Latest results show consistently increased VCN (Vector Copy Number) per cell in the range of 3 copies per genome and high gene expression in patients 6 month after HSC therapy. This effect of an increase of vector copy numbers can also be observed for T-cells, leading to a higher transduction efficiency applying LentiBOOST®, which in return allows higher levels of expression of your therapeutic proteins.
LentiBOOST® research grade material is used for basic research only - not transferable to the clinic
LentiBOOST® pharma grade non-GMP material is used for preclinical research and process development including large scale runs
LentiBOOST® GMP material is for clinical use - Sirion holds a patent (published as WO2013127964) for this substance class and licenses the technology for clinical use. LentiBOOST® GMP material is available for process development (GMP pilot runs) under a research or clinical license. Please contact firstname.lastname@example.org
Note: product availability depends on country - see product detail page.
|Details||Cat number & supplier||Size||Price|
|LentiBOOST® Pharma Grade Lentivirus Transduction Enhancer Solution, 40 Transductions SB-P-LV-101-10 · SIRION Biotech||
|LentiBOOST® Pharma Grade Lentivirus Transduction Enhancer Solution, 100 Transductions SB-P-LV-101-11 · SIRION Biotech||
|LentiBOOST® Pharma Grade Lentivirus Transduction Enhancer Solution, 200 Transductions SB-P-LV-101-12 · SIRION Biotech||
|LentiBOOST® Research Grade Lentivirus Transduction Enhancer Solution, 200 Transductions SB-P-LV-101-03 · SIRION Biotech||