IL-10, mouse recombinant
Interleukin-10 (IL-10) is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells. IL-10 inhibits the production of pro-inflammatory cytokines such as interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha), interleukin-2 (IL-2), interleukin-3 (IL-3), interleukin-4 (IL-4) and granulocyte-macrophage colony-stimulating factor (GM-CSF), made by macrophages and regulatory T cells. IL-10 also suppresses antigen presentation on antigen presenting cells and enhances the survival, proliferation and antibody production of B cells. Mouse IL-10 is not active on human cells.
Peptides & proteins
Cytokine synthesis inhibitory factor, CSIF
at -20°C
at least 12 months
NAME: Interleukin IL-10 ; ACCESSION/UNIPROT#: P18893; EXPRESSION SYSTEM: E.coli; FORMAT: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5. Reconstitute in sterile water at 0.1 mg/mL.; TESTING: MC/9 cell proliferation with an acceptance criteria of 5 ng/mL (ED50), 2.0 x 10^5 units/mg.; #AA: 161; SEQUENCE: MSRGQYSRED NNCTHFPVGQ SHMLLELRTA FSQVKTFFQT KDQLDNILLT DSLMQDFKGY LGCQALSEMI QFYLVEVMPQ AEKHGPEIKE HLNSLGEKLK TLRMRLRRCH RFLPCENKSK AVEQVKSDFN KLQDQGVYKA MNEFDIFINC IEAYMMIKMK S