NT-3, human recombinant
Neurotrophin-3 (NT-3) is an important member of the nerve growth factor (NGF) family of proteins behind BDNF and NGF. It is thought to promote the survival or differentiation of existing and new neurons in the central nervous system and synapses. These functions are thought to be communicated by TrkC, a receptor tryrosine kinase thought induce NT-3-specific signaling. In addition, NT-3 is thought to also bind TrkB and low affinity nerve growth factor receptor (LNGFR). Recombinant human NT-3 is a non-glycosylated, non-covalently linked homodimer.
Peptides & proteins
Neurotrophin 3, Nerve growth factor 2 (NGF-2), HGNF, NT3, Neurotrophic Factor
-20°C
NAME: Neurotrophin-3; ACCESSION/UNIPROT#: P20783; EXPRESSION SYSTEM: E.coli; FORMAT: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA). Reconstitute in sterile water at 0.1 mg/mL.; TESTING: C6 cell proliferation with an acceptance criteria of 20 ug/mL (ED50), 50 units/mg.; #AA: 240; SEQUENCE: MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT