IL-15, human recombinant
Interleukin-15 (IL-15) is a pleiotropic pro-inflammatory cytokine that promotes activation of T cells, neutrophils and macrophages, and is critical to dendritic cell function in several model systems. IL-15 has been shown to play a role in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases. Emerging data suggest that IL-15 may serve as a good therapeutic target as there appears to be a beneficial effect of IL-15 neutralization in models of psoriasis and diabetes. Recombinant human IL-15 is a single, non-glycosylated polypeptide chain.
Peptides & proteins
IL-T
-20°C
NAME: Interleukin-15; ACCESSION/UNIPROT#: P40933; EXPRESSION SYSTEM: E.coli; FORMAT: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium bicarbonate, pH 8.0. Reconstitute in sterile water at 0.1 mg/mL.; TESTING: CTLL-2 cell proliferation with an acceptance criteria of 5 ng/mL (ED50), 2 x 10^5 units/mg.; #AA: 115; SEQUENCE: MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS