IL-13, human recombinant
Interleukin-13 (IL-13) is a multifunctional cytokine whose net principle action is to diminish inflammatory responses. IL-13 is an important cytokine secreted from type 2 helper T lymphocytes. It is essential for modulating IgE synthesis by human B cells. Previous studies showed that polymorphisms in the IL-13 gene were associated with serum total IgE or allergic asthma. IL-13 is a pleiotropic cytokine, which shares many biological functions with IL-4. The receptor subunits of IL-13 consist of IL- 4Ralpha, IL-13Ralpha1 and IL-13Ralpha2. Recombinant Human IL-13 is a variant of native IL-13, containing 115 amino acids (additional Gln at position 113) and a molecular weight of 12.6 kDa.
Peptides & proteins
NC30
-20°C
NAME: Interleukin-13; ACCESSION/UNIPROT#: P35225; EXPRESSION SYSTEM: E.coli; FORMAT: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium citrate, pH 3.0. Reconstitute in sterile 10 mM HCl at 0.1 mg/mL.; TESTING: TF-1 cell proliferation with an acceptance criteria of 5 ng/mL (ED50), 2 x 10^5 units/mg.; #AA: 115; SEQUENCE: MSPGPVPPSTA LRELIEELVN ITQNQKAPLC NGSMVWSINL TAGMYCAALE SLINVSGCSA IEKTQRMLSG FCPHKVSAGQ FSSLHVRDTK IEVAQFVKDL LLHLKKLFRE GRQFN