Follistatin, human recombinant
Follistatin is an autocrine acting protein that is expressed by many tissues, but at noteably higher levels in the ovary and skin. Follistatin functions to negatively regulate the signaling of a wide variety of TGF-beta family members (activin, BMPs, myostatin, GDF-11 and TGF-beta 1). Mechanistically, follistatin works as an antagonist by complexing with TGF-beta family members to prevent them from interacting with their signaling receptors. Recombinant human Follistatin is a non-glycosylated protein.
Peptides & proteins
FS, activin-binding protein, FSH-suppressing protein (FSP)
-20°C
NAME: Follistatin; ACCESSION/UNIPROT#: P19883; EXPRESSION SYSTEM: E.coli; FORMAT: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, 50mM sodium chloride, pH 7.5. Reconstitute in sterile water at 0.1 mg/mL.; TESTING: Neutralization of human Activin A with an acceptance criteria of 200 ng/mL (ED50), 5.0 x 10^3 units/mg.; #AA: 289; SEQUENCE: MGNCWLRQAK NGRCQVLYKT ELSKEECCST GRLSTSWTEE DVNDNTLFKW MIFNGGAPNC IPCKETCENV DCGPGKKCRMNKKNKPRCVC APDCSNITWK GPVCGLDGKT YRNECALLKA RCKEQPELEV QYQGRCKKTC RDVFCPGSST CVVDQTNNAY CVTCNRICPEPASSEQYLCG NDGVTYSSAC HLRKATCLLG RSIGLAYEGK CIKAKSCEDI QCTGGKKCLW DFKVGRGRCS LCDELCPDSK SDEPVCASDNATYASECAMK EAACSSGVLL EVKHSGSCN