Myostatin, human recombinant
Myostatin (GDF8) is a member of the transforming growth factor beta superfamily that is essential for proper regulation of skeletal muscle mass. Myostatin is a secreted protein that negatively regulates skeletal muscle mass determining both muscle fiber number and size. The myostatin pathway is conserved and regulates muscle mass in a number of animal species ranging from fish to humans. Inhibition of myostatin using a variety of therapeutic approaches can increase muscle mass in a number of animal models of human disease, including muscular dystrophy. Recombinant Human Myostatin is a homodimer, non-glycosylated polypeptide chain.
Peptides & proteins
GDF-8, MSTN
at -20°C
at least 12 months
NAME: Myostatin; ACCESSION/UNIPROT#: O14793(267-375); EXPRESSION SYSTEM: E.coli; FORMAT: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA). Reconstitute in sterile 20 mM HCI at 0.1 mg/mL.; TESTING: MCP-11 cell cytoxicity with an acceptance criteria of 50 ng/mL (ED50), 2.0 x 10^4 units/mg.; #AA: 218; SEQUENCE: DFGLDCDEHS TESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGECEFV FLQKYPHTHL VHQANPRGSA GPCCTPTKMS PINMLYFNGK EQIIYGKIPA MVVDRCGCS