SU5402

SU5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor. Multiple myeloma studies suggest that SU5402 inhibits FGFR3 phosphorylation in-vitro. Additionally, SU5402 has been observed to inhibit IL-1 beta-induced MAPK activity. SU5402 is used in an embryonic stem cells (ESC) culture method with three inhibitors (3i: SU5402 for FGFR, PD184352 for ERK, and CHIR99021 for GSK3). It has been showed that this 3i method is extremely instrumental in establishing and culturing germline-competent ESC. It inhibits embryonic left-right determination and exhibits potent anticancer activity in-vitro and in-vivo.