Bongkrekic Acid
MPT pore opening inhibitor / A potent inhibitory ligand of the mitochondrial adenine nucleotide translocase (ANT)1. Inhibits mitochondrial permeability transition pore opening2,3. Delivery of bongkrekic acid to the mitochondria prevents apoptosis in HeLa cells4.
Biochemicals & reagents
11076-19-0
1) Ziegler et al. (1993), The adenine nucleotide translocase modulates oligomycin-induced quenching of pyranine fluorescence in submitochondrial particles; J. Biol. Chem., 268 25320 2) Marchetti et al. (1996), Mitochondrial permeability transition triggers lymphocyte apoptosis; J. Immunol., 157 4830 3) Zamzami et al. (1996), Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis; FEBS Lett., 384 53 4) Yamada et al. (2013), Mitochondrial delivery of bongkrekic acid using a MITO-Porter prevents the induction of apoptosis in human HeLa cells; J. Pharm. Sci., 102 1008
-20°C
PATHWAY: Mitochondrial function; Apoptosis inhibitor -- RESEARCH AREA: Cell death