Induces ROS generation / DMNQ is a non-alkylating redox cycling quinone. A useful tool for studying reactive oxidant species and oxidative stress. Cellular effects are dependent on concentration and cell type.
Biochemicals & reagents
6956-96-3
1) Gant et al. (1988) Redox Cycling and Sulphydryl Arylation; Their Relative Importance in the Mechanism of Quinone Cytotoxicity to Isolated Hepatocytes Chem.-Biol. Interactions 65 157 2) Stubberfield and Cohen (1989) Interconversion of NAD(H) to NADP(H). A cellular response to quinone-induced oxidative stress in isolated hepatocytes Biochem.Pharmacol. 38 2631 3) Dypbukt et al (1994) Different prooxidant levels stimulate growth, trigger apoptosis or produce necreosis of insulin-secreting RINm5F cells. The role of intracellular polyamines. J.Biol.Chem. 269 30553. 4) Henry and Wallace (1996) Differential mechanisms of cell killing by redox cycling and arylating quinones Arch.Toxicol. 70 482
-20°C
RESEARCH AREA: Oxidative stress -- DISEASE AREA: Diabetes