N-Oleoylphenylalanine
Endogenous uncoupler of mitochondrial respiration / An endogenous lipoamino acid produced via the action of a secreted enzyme PM20D1 produced by adipocytes. N-Oleoylphenylalanine binds directly to mitochondria and functions as an endogenous uncoupler of UCP1-independent respiration and is the most potent in the group of structurally different lipoamino acids evaluated. Mice treated with an analog, C18-1-Leu, were found to have improved glucose homeostasis and increased energy expenditure.1
Biochemicals & reagents
136560-78-6
NOPA; C18-1-Phe
1) Long et al. (2016), The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria Cell, 166 424
-20°C
PATHWAY: Carbohydrate metabolism; Mitochondrial function -- DISEASE AREA: Diabetes