E1 UAE inhibitor / Inhibits ubiquitin activating enzyme E1 (>60% inhibition at 10 µM) with little or no activity against E2 or E3. Cell permeable
Product Type:
Biochemicals & reagents
CAS Number:
418805-02-4
Reference:
1) Yang et al. (2007), Inhibitors of Ubiquitin-Activating Enzyme (E1), a New Class of Potential Cancer Therapeutics; Cancer Res., 67 9472. / 2) Mi et al. (2009), Cancer Preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes; J. Biol. Chem., 284 17039
Storage Temperature:
-20°C
Additional Information:
TARGET: UAE (ubiquitin activating enzyme) -- PATHWAY: Degradation -- RESEARCH AREA: Ubiquitin/Proteasome