Tryptanthrin
Immunomodulator; IDO2 inhibitor / A indoloquinazoline alkaloid found in various plant species and possessing intriguing pharmacological activities.1 Suppresses activation of BV2 microglia cells following LPS treatment and reduces production of proinflammatory cytokines via Nrf2, HO-1 and NFκB signaling.2 Displays antiinflammatory activity targeting IL-17.3 Inhibits indoleamine 2,3-dioxygenase 2 (IDO2) with an IC50 of 5-17 μM.4 Induces growth inhibition and neuronal differentiation in human neuroblastoma LA-N-1 cells.5
Biochemicals & reagents
13220-57-0
NSC 349447; Couroupitine A
1) Jahng et al. (2013), Progress in the studies on tryptanthrin, an alkaloid of history; Arch. Pharm. Res., 36 517 2) Kwon et al. (2017), Tryptanthrin Supresses the Activation of the LPS-Treated BV2 Microglial Cell Line via Nrf2/HO-1 Antioxidant Signaling; Front. Cell. Neurosci., 11 18 3) Cheng et al. (2017), Clinical efficacy and IL-17 targeting mechanism of Indigo naturalis as a topical agent in moderate psoriasis; BMC Complement. Altern. Med., 17 439 4) Li et al. (2016), Establishment of a human indoleamine 2,3-dioxygenase 2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors; Eur. J. Med. Chem., 123 171 5) Liao and Leung (2013), Tryptanthrin induces growth inhibition and neuronal differentiation in the human neuroblastoma LA-N-1 cells Eur. Chem. Biol. Interact., 203 512
-20°C
TARGET: Tryptophan -- PATHWAY: Cytokine; Amino acid metabolism; IDO/TDO pathways; NFkappaB -- RESEARCH AREA: Immunology -- DISEASE AREA: Inflammation