24,25-Epoxycholesterol
LXR agonist / Cholesterol metabolite. Endogenous agonist for nuclear receptor LXR1. Controls cellular cholesterol homeostasis2. Promotes neural development in zebra fish as well as dopaminergic differentiation of embryonic stem cells3. Cell permeable.
Biochemicals & reagents
77058-74-3
1) Chawla et al. (2001), Nuclear receptors and lipid physiology: opening the X-files; Science, 294 1866 2) Brown et al. (2009), 24(S),25-epoxycholesterol: a messenger for cholesterol homeostasis; Int. J. Biochem. Cell Biol., 41 744 3) Theofilopoulos et al. (2013), Brain endogenous liver X receptor igands selectively promote midbrain neurogenesis; Nature Chem. Biol., 9 126
-20°C
TARGET: Transcription factor -- PATHWAY: Cholesterol metabolism; Transcription -- RESEARCH AREA: Neuroscience; Stem cells -- DISEASE AREA: Neurodegeneration