27-Hydroxycholesterol
Cholesterol metabolite / Metabolite resulting from the action of sterol 27-hydroxylase on cholesterol. Concentrations of 27-hydroxycholesterol are elevated in patients with Alzheimers disease and mild cognitive impairment.1,2 Endogenous selective estrogen receptor modulator3 and ligand for the liver X receptor(EC50 = 85nM for LXRα and 71nM for LXRβ)4.
Biochemicals & reagents
20380-11-4
1) Heverin et al. (2004), Changes in the levels of cerebral and extracerebral sterols in the brains of patients with Alzheimer’s disease; J.Lipid Res. 45 186 2) Shafaati et al. (2011), Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer’s patients with the Swedish APP 670-671 mutation; J.Lipid Res. 52 1004 3) Umetani et al. (2007), 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen; Nature Medicine, 13 1185 4) Fu et al. (2001), 27-Hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells; J.Biol.Chem. 276 38378
-20°C
TARGET: Transcription factor -- PATHWAY: Cholesterol metabolism; Estrogen; Transcription -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Neurodegeneration