Guggulsterone-(Z)
FXR antagonist / A natural steroid from Commiphora mukul extract (guggulipid) which lowers cholesterol and acts as an FXR antagonist.1 Attenuates astrocyte-mediated neuroinflam-mation.2 Induces differentiation of pluripotent stem cells to dopaminergic neurons.3 Produces antidepressant-like effects via activation of the BDNF signaling pathway in mouse models.4
Biochemicals & reagents
39025-23-5
1) Urizar et al. (2002), A Natural Product That Lowers Cholesterol as an Antagonist Ligand for FXR; Science, 296 1703 2) Liu et al. (2018), Z-guggulsterone attenuates astrocytes-mediated neuroinflammation after ischemia by inhibiting toll-like receptor 4 pathway; J. Neurochem., 147 803 3) Agbay et al. (2018), Guggulsterone-releasing Microspheres Direct the Differentiation of Human Induced Pluripotent Stem Cells Into Neural Phenotypes; Biomed. Mater., 13 034104 4) Liu et al. (2017), Z-Guggulsterone Produces Antidepressant-Like Effects in Mice through Activation of the BDNF Signaling Pathway; Int. J. Neuropsychopharmacol., 20 485
-20°C
TARGET: Transcription factor -- PATHWAY: Transcription; Cholesterol metabolism; NFkappaB; AKT; JAK/STAT; Glucose metabolism -- RESEARCH AREA: Neuroscience; Immunology; Stem cells -- DISEASE AREA: Inflammation; CancerMood disorders; Obesity; Diabetes