GSK-3787
PPARδ antagonist / GSK-3787 is a selective and irreversible antagonist of the peroxisome proliferator-activated receptor delta (PPARdelta) – plC50 = 6.6. It covalently binds to Cys 249 in the PPARdelta binding site.
Biochemicals & reagents
188591-46-0
1) Shearer et al., (2010) Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist J. Med. Chem. 53 1857 / 2) Palkar et al. (2010) Cellular and pharmacological selectivity of the peroxisone proliferator-activated receptor-β/δ antagonist GSK3787 Mol. Pharmacol. 78 419
-20°C
TARGET: Transcription factor -- PATHWAY: PPAR; Transcription; Proliferation; Mitochondrial function -- RESEARCH AREA: Wound healing -- DISEASE AREA: Cancer; Inflammation