DiMNF
AhR modulator (SAhRM) / DiMNF is a selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). It exhibits antiinflammatory activity including suppression of cytokine-mediated acute phase genes through dissociation of non-dioxin-response element (DRE) AHR activity from DRE-dependent xenobiotic gene expression1. Represses the cytokine-mediated induction of CD55 and therefore may have therapeutic potential in regulating the immune response to tumor formation2. Represses estrogen-inducible transcription3.
Biochemicals & reagents
14756-24-2
3’,4’-Dimethoxy-α-naphthoflavone
1) Murray et al. (2011), Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3’,4’-dimethoxy-α-naphthoflavone; Mol. Pharmacol., 79 508 2) Narayanan et al. (2012), Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure; J. Pharmacol. Exp. Ther., 342 345 3) Labrecque et al. (2012), Distinct roles for aryl hydrocarbon receptor nuclear translocator and ah receptor in estrogen-mediated signaling in human cancer cell lines; PLoS One, 7(1) e29545
-20°C
TARGET: Transcription factor -- PATHWAY: Cytokine; Transcription -- RESEARCH AREA: Immunology -- DISEASE AREA: Cancer; Inflammation