TCPOBOP

Name: TCPOBOP
Brand: Focus Biomolecules
SKU: 10-1088-02
Price: 120 GBP
Availability: InStock

Supplier:

Focus Biomolecules

Catalogue number:

10-1088-02

Size:

25 mg

Product is available in:

$120.00

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CAR agonist / TCPOBOP is an activator of the mouse constitutive androstane receptor (mCAR) and human Preganane X receptor.1 Tumor promoter of mouse hepatocarcinogenesis

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Product Type:

Biochemicals & reagents

CAS Number:

76150-91-9

Reference:

1) Tzameli et al (2000) The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR. Mol.Cell.Biol. 20 2951 / 2) Diwan et al. (1992) Tumor-promoting and hepatocarcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in DBA/2NCr and C57BL/6NCr mice and an apparent promoting effect on nasal cavity tumors but not on hepatocellular tumors in F344/NCr rats initiated with N-nitrosodiethylamine. Carcinogenesis 13 1893

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Additional Information:

TARGET: Transcription factor -- PATHWAY: DNA damage; Chromatin; Transcription; Posttranslational modification -- DISEASE AREA: Cancer