NSC59984
p53 activator / p53 activator. Restores wild-type p53 signaling and depletes mutant p53 gain of function. Induces mutant p53 protein degradation via MDM2 and ubiquitin-proteasome pathway. Induces p73-dependent cell death in cancer cells without toxicity toward normal cells.1 Inhibition of p53-MDM2 interaction remains a viable strategy for cancer therapeutic development.2,3
Biochemicals & reagents
803647-40-7
1) Zhang et al. (2015), Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53; Cancer Res., 75 3842 2) Ferraiuolo et al. (2016), Oncogenic Intra-p53 Family Member Interactions in Human Cancers; Front. Oncol., 6 77 3) Hong et al. (2014), Targeting tumor suppressor p53 for cancer therapy: strategies, challenges and opportunities; Curr. Drug Targets, 15 80
-20°C
TARGET: Transcription factor -- PATHWAY: p53; Transcription -- RESEARCH AREA: Ubiquitin/Proteasome; Cell death -- DISEASE AREA: Cancer