SR-717
Supplier:
Catalogue number:
10-4850-01
Size:
10 mg
Product is available in:
STING agonist / Cell permeable and exceptionally selective STING agonist (IC50 = 7.8 µM). It displayed robust antitumor activity in B16.F10 melanoma and MC38 colorectal adenocarcinoma mouse models. SR-717 promoted the activation of CD8+ T, natural killer, and dendritic cells as well as promoting antigen cross-priming. It was able to induce PD-L1 expression in THP1 cells and in primary human PBMC’s.
Product Type:
Biochemicals & reagents
CAS Number:
2375421-09-1
Reference:
Chin et al. (2020), Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic; Science 369 993
Storage Temperature:
-20°C
Additional Information:
TARGET: STING -- PATHWAY: Cytokine -- RESEARCH AREA: Immunology -- DISEASE AREA: Cancer