TC-E 5003
Supplier:
Catalogue number:
10-1499-02
Size:
250 mg
Product is available in:
Arginine methyl transferase 1 (PRMT1) inhibitor / Selective protein arginine methyltransferase 1 (PRMT1) inhibitor, IC50 = 1.5 μM. Displays no activity against CARM1 and Set7/9 methyltransferases. Inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells. Blocks androgen-induced gene expression in LNCaP cells1.
Product Type:
Biochemicals & reagents
CAS Number:
17328-16-4
Reference:
1) Bissinger et al. (2011), Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methytransferase hPRMT1; Bioorg. Med. Chem., 19 3717
Storage Temperature:
-20°C
Additional Information:
TARGET: Protein methyltransferase -- PATHWAY: Chromatin; Posttranslational modification; Transcription -- RESEARCH AREA: Epigenetics