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TC-E 5003

Supplier:
Catalogue number:
10-1499-02
Size:
250 mg
Product is available in:
  • USA
  • Canada
$240.00 Shipping is calculated in checkout

Arginine methyl transferase 1 (PRMT1) inhibitor / Selective protein arginine methyltransferase 1 (PRMT1) inhibitor, IC50 = 1.5 μM. Displays no activity against CARM1 and Set7/9 methyltransferases. Inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells. Blocks androgen-induced gene expression in LNCaP cells1.

Product Type:

Biochemicals & reagents

CAS Number:

17328-16-4

Reference:

1) Bissinger et al. (2011), Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methytransferase hPRMT1; Bioorg. Med. Chem., 19 3717

Storage Temperature:

-20°C

Additional Information:

TARGET: Protein methyltransferase -- PATHWAY: Chromatin; Posttranslational modification; Transcription -- RESEARCH AREA: Epigenetics