Methyl transferase inhibitor / Potent histone methyltransferase inhibitor which decreases global histone methylation1. Inhibits trimethylation of H3K27 and H4K20 in vitro1. Selectively induces apoptosis in multiple cancer cell lines with no effect on normal cells2. May be used in cocktails to chemically induce pluripotent stem cells (CiPSCs) from somatic cells3. Enhances angiogenesis in a mouse model of limb ischemia4.
Biochemicals & reagents
120964-45-6
3-Deazaneplanocin A, HCl; NSC 617989
1) Miranda et al. (2009), DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation; Mol. Cancer Ther., 8 1579 2) Tan et al. (2007), Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells; Genes Dev., 21 1050 3) Hou et al. (2013), Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds; Science, 341 651 4) Mitic et al. (2015), EZH2 modulates angiogenesis in vitro and in a mouse model of limb ischemia; Mol. Ther., 23 32
-20°C
TARGET: Protein methyltransferase -- PATHWAY: Chromatin; Posttranslational modification; Apoptosis inducer -- RESEARCH AREA: Epigenetics; Cell death; Stem cells; Angiogenesis -- DISEASE AREA: Cancer; Ischemia