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Splitomicin

Supplier:
Catalogue number:
10-2615-01
Size:
5 mg
Product is available in:
  • USA
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Sirt1 inhibitor / Initially shown to inhibit Sir2p (the yeast Sirt1 homolog) and create a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae1. Cells grown in the presence of the drug have silencing defects at telomeres, silent mating-type loci and the ribosomal DNA1. Inhibits all class III HDACs (sirtuins) and alleviates gene silencing in Fragile X mental retardation syndrome2. Reverses ischemic preconditioning-induced cardioprotection in a mouse model3.

Product Type:

Biochemicals & reagents

CAS Number:

1382877

Additional Information:

TARGET: Protein deacetylase -- PATHWAY: Chromatin; Posttranslational modification -- RESEARCH AREA: Epigenetics -- DISEASE AREA: Heart disease; Ischemia