Scriptaid
HDAC inhibitor / Inhibits histone deacetylases (HDAC) 1 and 3 (IC50~0.6 uM) and HDAC8 (IC50~1 uM) and is less toxic compared to trichostatin A.1,2 Induces cell cycle arrest and epigenetic changes in colon cancer cells.3 Together with DRB-inhibition of RNA synthesis, scriptaid enhances gene reprogramming in somatic cell nuclear transfer (SCNT) embryos.4 Increases exercise endurance in mice.5
Biochemicals & reagents
287383-59-9
Scriptide; GCK1026
1) Su et al. (2000), A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library; Cancer Res., 60 3137 2) Huber et al. (2011), Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells; J. Biol. Chem., 286 22211 3) Lee et al. (2008), Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells; J. Oncol., 33 767 4) Rissi et al. (2019), Inhibition of RNA synthesis during Scriptaid exposure enhances gene reprogramming in SCNT embryos; Reproduction, 157 123 5) Huang et al. (2020), Scriptaid/exercise-induced lysine acetylation is another type of posttranslational modification occurring in titin; J. Appl. Physiol., 128 276
-20°C
TARGET: Protein deacetylase -- PATHWAY: Chromatin; Posttranslational modification; Cell cycle; Proliferation -- RESEARCH AREA: Epigenetics; Stem cells -- DISEASE AREA: Cancer