SAHA (Vorinostat)
HDAC inhibitor / Potent and selective histone deacetylase inhibitor. Induces apoptosis in a variety of tumor cell lines. Synergizes with kinase inhibitors to kill CNS tumor cells. Cell permeable.
Biochemicals & reagents
149647-78-9
Vorinostat
1) Vrana et al. (1999), Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun and p21CIP1, but independent of p53; Oncogene, 18 7016 / 2) Butler et al. (2002), The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin; Proc. Natl. Acad. Sci. USA, 99 11700 / 3) Tang et al. (2012), Sorafenib and HDAC inhibitors synergize to kill CNS tumor cells, 13 567
RT
TARGET: Protein deacetylase -- PATHWAY: Chromatin; Apoptosis inducer; Posttranslational modification -- RESEARCH AREA: Epigenetics; Cell death; Stem cells -- DISEASE AREA: Cancer