Q-VD-OPH
Caspase inhibitor (pan) / Q-VD-OPh is a potent and highly effective pan-caspase inhibitor with potent antiapoptotic activity which is not toxic to cells.1 Displays protective effects on brain damage and bacterial infection in a murine MCAO stroke model.2 Switches doxorubicin-induced apoptosis to an alternative default cell death mode marked by increased expression of senescence markers.3 Blocks staurosporin-induced differentiation of embryonic stem cells to cardiomyocytes.4 Trophoblasts treated with ceramide and Q-VD-OPh undergo necroptosis.5
Biochemicals & reagents
1135695-98-5
1) Caserta et al. (2003), Q-VD-OPh, a broad spectrum caspase inhibitor with potent antapoptotic properties; Apoptosis, 8 345 2) Braun et al. (2007), Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH; Exp. Neurol., 206 183 3) Rebbaa et al. (2003), Caspase inhibition switches doxorubicin-induced apoptosis to senescence; Oncogene, 22 2805 4) Bulatovic et al. (2015), Sublethal caspase activation promotes generation of cardiomyocytes from embryonic stem cells; PLoS One, 10 e0120176 5) Bailey et al. (2017), Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis; Cell Death Dis., 8 e2590
-20°C
TARGET: Protease -- PATHWAY: Necroptosis; Apoptosis inhibitor; Senescence -- RESEARCH AREA: Stem cells; Cell death -- DISEASE AREA: Infectious disease; IschemiaAgeing